广西壮族腰椎间盘突出症血瘀证患者与TGF-β一 -五0九C/T基因多态

    作者：许建文　钟遥叫　陈晶　欧伦　谢伟星　尹利军　张家立　杨光　韦家鼎　李桂焕 

【摘要】  ［目的］探讨腰椎间盘突出症血瘀证患者及部门危险因素与TGF-β一 -五0九C/T基因多态性的联络瓜葛性。［法子］挑选相符既定相干尺度的广西壮族人群腰椎间盘突出症患者八八例,分为血瘀证组三0例与非血瘀证组五八例，入行TGF-β一 -五0九C/T基因多态性检测，并观测患者的腰椎负荷强度等指标，察看部门危险因素和部门危险因素以及TGF-β一 -五0九C/T基因多态性的交互作用与腰椎间盘突出症中医证型的联络瓜葛性。［结果］经非条件Logistic归回Forward（LR）法分析显示广西壮族重度腰椎负荷强度者患腰椎间盘突出症血瘀证的风险是轻中度腰椎负荷强度者的三.九一一倍（九五%CI:一.三三四～ 一.八七二）(P<0.0五)，TGF－β一 基因-五0九C/T多态性与重度腰椎负荷强度的积累暴露产生腰椎间盘突出症血瘀证的风险是其中某单1因素的一八.四二五倍（九五%CI:一.七六七～ 三.六九三）(P<0.0一)。［结论］重度腰椎负荷强度很多是广西壮族人腰椎间盘突出症血瘀证的潜在危险因素之1，TGF－β一 基因-五0九位点CT基因型与重度腰椎负荷强度积累暴露更容易产生血瘀型腰椎间盘突出症。

【关键词】  腰椎间盘突出症　中医证型　 危险因素　TGF-β一 -五0九C/T基因多态性
   
　　Abstract: ［Objective］To investigate the relationship between the blood stasis syndrome and parts of the risk factors of lumbar intervertebral disk protrusion (LIDP)and transforming growth factor β一 (TGF-β一) -五0九C/T site gene polymorphisms.  ［Methods］A total of 八八 Zhuang ethnic patients from Guangxi Zhuang Autonomous Region were selected according to standard of LIDP, 三0 with blood stasis syndrome and the other 五八 without , then, their single nucleotide polymorphism (SNP) of TGF-β一 -五0九C/T and risk factors like lumbar burden intensity were tested, and their relationship with the traditional Chinese medicine syndrome of LIDP were analyzed.［Results］It was showed by logistic regression  Forward (LR) analysis that risk of syndrome of blood stasis pattern of LIDP in patients with severe lumbar burden was  三.九一一 times （九五%CI:一.三三四～一.八七二）of that in patients with mild and middle lumbar burden (P<0.0五) , and the risk further increased 一八.四二五 times（九五%CI:一.七六七～ 三.六九三）after it's accumulating with TGF-β一 -五0九C/T site gene polymorphisms in Zhuang ethinic group in Guangxi(P<0.0一).［Conclusion］Severe lumbar burden may be one of the risk factors of syndrome of blood stasis pattern of LIDP in Zhuang ethnic populational from Guangxi. Patients with TGF-β一 gene－五0九 adiponectin CT genotype and combined severe lumbar burden are susceptible to syndrome of blood stasis pattern of  LIDP.
   
　　Key  words：lumbar  intervertebral  disk  protrusion;  syndrome pattern of  traditional  Chinese  medinine;  risk  factors;  transforming growth factor-β一 -五0九C/T gene  polymorphisms
   
　　腰椎间盘突出症（lumbar  intervertebral  disk  protrusion ,LIDP) 是最多见的脊柱骨科疾病，中医辨证以血瘀证多见，海内外学者钻研多年，但腰腿痛反复产生发火仍是目前不少医生以及患者没法归避的题目。本文探讨TGF-β一 -五0九C/T(transforming  growth  factor  β一,转化生长因子β一)基因多态性及部门危险因素与LIDP血瘀证的联络瓜葛性，为入1步钻研本病防治措施提供参考。

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