作者：石艳 杨玉湘 杨尧 戴莉 王西蓉 黄婷婷 张海
【摘要】目的 研究川崎病(KD)患儿血小板参数变化及与冠状动脉损害的关系。方法 对确诊为KD的293例患儿分别测定其急性期即入院发热时及恢复期即热退1周内血小板数(PLT)、平均血小板体积(MPV)、血小板分布宽度(PDW)、血小板压积(PCT)，同时测定300例同期年龄相仿发热患儿(非KD及血液系统疾病)血小板参数作为对照。对有和无冠状动脉异常患儿血小板参数分别进行比较。并对血小板各参数进行相关性分析。结果 KD患儿PLT、PCT升高，恢复期较急性期更显著(P<O.001)。恢复期MPV、PDW降低。PLT与MPV呈负相关，与PCT呈正相关。MPV与PDW呈正相关。冠状动脉异常患儿与无异常患儿血小板参数比较无显著差异性(P>0．05)。结论 血小板参数变化有助于KD诊断，但至少目前不能作为预测冠状动脉损害的指标。
【关键词】川崎病 血小板参数 诊断 预后
【Abstract】Objective: To investigate the relation between changes of platelet parameters of children with Kawasaki disease (KD) and coronary artery damage. Methods: Platelet count (PLT)，mean platelet volume (MPV)，platelet distribution width (PDW) and plateletcrit (PCT) of 293 KD children were detected in the acute phase when these children were hospitalized and having fever and in recovery phase within 1 week after abatement of the fever. The platelet parameters above were also tested in 300 children with fever at similar age over the same period (without KD，and blood diseases) as control. Platelet parameters of children with or without coronary artery abnormalities were compared. Correlation analysis was carried out on these platelet parameters. Results: The PLT and PCT of KD children significantly increased in recovery phase compared with that in the acute phase (P <O.001). MPV and PDW reduced in recovery phase. PLT was negatively correlated with MPV and were positively correlated with the PCT. MPV and PDW were positively correlated. Platelet parameters showed no significant difference among children with or without coronary artery abnormalities(P>0.05).Conclusion: The platelet parameters contribute to KD diagnosis,but can not act as a predictive indicator for coronary artery damage till now.
【Key words】 Kawasaki disease Platelet parameters Diagnosis Prognosis
川崎病(Kawasaki disease，KD)是一种原因不明的儿童常见的免疫相关性血管炎综合征[1]。主要病理改变为全身非特异性血管炎，累及中小血管特别是冠状动脉。可形成冠状动脉瘤，引起血栓性梗塞、狭窄，导致心肌梗塞、猝死，需及时有效的治疗[2]。近年来研究表明，血小板参数与KD的发病及冠状动脉的损害有关[3]，为进一步探讨其相关性，我们对其进行了大样本的研究，现报道如下：
1 资料与方法
1.1 一般资料 回顾分析我州17个县市各医院儿科从2002年1月-2010年11月住院的307例符合要求的KD患儿的临床资料，307例患儿中临床资料完整的293例。男175例，女118例，男女比例为1.48：1。年龄最小的3个月，最大的13岁，分别在起病2—10d住院。
1.2 以同期年龄相仿发热住院患儿300例(非KD和血液系统疾病)为对照组，各组观察对象的年龄、性别比较P＞0.05，具有可比性。
百度搜索“yundocx”或“云文档网”即可找到本站免费阅读全部范文。收藏本站方便下次阅读，云文档网，提供经典医药类川崎病患儿血小板参数变化的临床研究在线全文阅读。
最新更新：
